This is saving my life. After 20 days, I have slowly raised the daily dose to 120,000 SPUs. That's as high as I'll go. So far it has begun to cure senior moments, sharp pains in my temples, and pain from osteoarthritis. I can now stand for longer without pain, and I can bend enough so that I can watch the stars while standing up. Symptoms of dementia and Parkinson's and Alzheimer's are all getting less and less frequent. Even my vertigo upon moving from my left side to my right side in bed is going away. Floaters in my right eye are a tiny bit better but I'll have to continue therapy for 6 months to really see if it eats up floaters.I have experienced NO side effect at all but I should mention that I take NO drugs, medications, ibuprofen, antacids, at all -- zero. I drink ONLY filtered water. I eat no gluten. I eat no meat. I eat no cheese. My digestive system is clear and clean. If yours is not, you might want to make it so before starting on these.This stuff has been WONDERFUL for my skin too. I used to have a bunch of pin-prick sores on my arms but no more and my skin feels like silk now. My face is clearing up.I can breathe through my nose for the first time in my memory. My sinuses are healthy, and I can better tolerate allergens like wood smoke and pollen. When I sneeze now, it feels good instead of painful. I no longer do mouth breathing so I wake up without dry mouth.I can see better now that the film that would form in my eyes overnight is lessened.The confusion I would sometimes experience that made me think I might be getting Alzheimer's is gone. And the mild symptoms that made me think I was getting Parkinson's have lessened.My little finger on my right hand that has osteoarthritis no longer hurts when I bend it back to stretch it.I can stand up straight again which means that I can stand and walk for longer distances before I have to sit down in my wheetchair.I fully believe that in 6 months time, I'll no longer need a wheelchair.I started with one 40,000 SPU pill on an empty stomach each day. I did that for about a week and then moved up to 2 pills at the same time every day for about a week. Then I moved to one 120,000 SPU pill a day and that will be my dose for 6 months. Then I'll move back down to one 40,000 SPU pill per day for maintenance.I have had ZERO side effects so far and tiny little improvements that are growing day by day.I fully believe that it is helping me cure every single beginning disorder that has to do with plaques: Alzheimer's, Parkinson's, heart disease, mini strokes, osteoarthritis, joint issues, vertigo, arteriosclerosis, breast cysts, and breathing issues.This is a miracle for me. I wish it would work this well for everyone. Please note that I do not smoke. I do not drink alcohol. I do not take ANY drugs or medications or prescription meds of any kind. I do not do recreational drugs. I do not eat meat or cheese or milk. I drink ONLY filtered water that is free of heavy metals. I do not take multi-vitamins. I take only a few supplements and I take them with my major meal at the end of the day while I take my pill on an empty stomach in the morning. I eat only potatoes, peas, powdered butter, apples, and other fruits and veggies some time. I also eat a lot of milk chocolate almond bars (my one vice). I do not eat any gluten. Most of the fruits and veggies I eat are organic and those that are not organic are GMO free. I drink about a gallon of filtered water every day.I sleep better now for fewer hours and get up fewer times during the night to pee since I've been taking the serrapeptase. I have great dreams.I am almost 70 years old and now that I've found serrapeptase, I can see myself living well past 100 years old. I wish others could take this supplement. Maybe they get the bad side effects because of other lifestyle choices that do not match my lifestyle choices? I don't know. I only know that this stuff is saving my life and saving my independence. I feel YOUNG again. I still have quite a ways to go before I can give up my wheelchair, but I fully believe I will get there before Winter starts in Nov 2017. I'll update this review then to tell you how I've done and whether I am out of my wheelchair for good. I have family members who died from Alzheimer's or Parkinson's or artery blockages (heart attacks or strokes), or respiratory issues. Now I have a way to make sure that I never get those issues and it costs just 13 cents a day.