I believe these have helped me with my Diverticulosis and have helped keep the disease calm and quiet, so I will continue taking them.This is one of the best probiotic's i have tried... However one should be careful in using this if they are constipated..this will make you more constipated. This is more suited for people who have diarrhea as their main symptom. for those who are constipated who want to try this product I suggest taking it once in three days or two days depending on how constipated you feel.. remember this product has 7 bifido strains which no other product has, bifido strains reside mainly in the colon 80 billion count and 7 bifido strains is more likely to cause constipation.. remember to refrigerate once u receive the product.. the best time to take this product is to take it first thing in the morning after you wake up with a glass of water.. one more thing be careful when you are using this product in combination with some other product .. this is not compatible with some products .. it is best to take this product alone..u can use this product for ibs,ibd, leaky gut etc. this doesn't have to be taken forever u can take this for 2 months and once the probiotics colonize the gi tract u can stop taking it , just take a maintenance dose once in a while and eat a diet rich in prebioticsI took RenewLife Ultimate Flora 15 Billion Blend for awhile and thought it helped a bit with my constant stomach struggles but wondered if another blend could help more. I did my research and came up with this 80 Billion Blend because it's targeted toward colon care. Well, I'm at the very beginning of this bottle (taking my 2nd capsule) and I can say with certainty that it's A LOT STRONGER than the 15 Billion Blend, which is not surprising. Basically, I feel bloated within the first hour of taking this capsule and my lower GI system feels mildly cramping although there's no symptoms of pain. But if I can't adjust after finishing this bottle (which will take me awhile since I can only take 2 capsules per week at this point) then I may have to work my way up to the 80 Billion Blend. From 15 Billion to 80 Billion was a huge jump. There's many steps in between. Did I also mention that this 80 Billion Blend is very much more expensive than the 15 Billion Blend?Took Renew Life 80 Billion Probiotics for two weeks and had zero results. Starting taking Physician's Choice Probiotics 60 Billion and had a normal bowel movement within two days. I have had chronic constipation for 40 yrs.Having had severe IBS and having tried many things, doctors, procedures, etc., these probiotics have been very helpful. I can buy them locally refrigerated but I pay more for them that way. Someone else commented on how the loss of a few (due to shipping with no refrigeration) is probably not a big issue. I don't know but I buy them both ways and find them very helpful. This is the only collection that includes all the kinds mentioned by a gut specialist on Dr. Oz's show. That initially motivated me to look for new probiotics and now, after some time, I have far fewer problems with IBS than I have in a long, long time. I think they are worth a try.I had my Gallbladder removed in 2003 and since then I have had issues with acid reflux and IBD. I have tried everything, the only thing that worked was medication that my Gastro Doctor prescribed but I was not going to be addicted to medicine so I bought this after trying many others and this is the ONE, this one works. No more meds and I swear by this probiotic, it is the answer and your pain and issues will be gone forever. I originally purchased it at Whole Foods and found it on Amazon for less. I have been ordering it for the last year on Amazon, best price.I had the best experience ever with this product. I wish there was even a higher potency. My tummy troubles were gone. I had a hard time digesting, cramps from the food and just didn't want to deal with the stress of it all. Thank goodness I did some research and found ultimate flora. It's a complete relief. No gas, no bloating, no heartburn, no cramps. It also helps to keep a balanced diet of fruits and vegetables and cut back on meat while using ultimate flora. I'm better and glad I took time to invest in my health with Ultimate Flora, its also way cheaper than trader j, whole fo.. and other health stores. Try it.Tuff CookieWith all the different types and kinds of Probio's out there Renew Life - Ultimate Flora Critical Colon 80 Billion is the one for all of you who have IBS, IBD, Crohns, leaky gut, etc... This is the one with the most correctional proboitics. I have IBD and this has cured me permanently, I can even drink alcohol now. Before I would have blood and a blockage after eating/drinking the wrong things. I doubled up on the dosage and took that for 2 months and viola back to normal and I can eat like a kid again. Also do some research on kefir if you like beer (water kefir) and yogurt (milk kefir) you are going to love this stuff. It will substitue for soda and smoothies